The 36-year-old centre-back last played for the club was in the 2-2 draw against Kasimpasa where he ruptured his Achilles in the club’s last league match in 2020
He joined Istanbul from Serie A side Atalanta after his contract was ripped up and just three weeks in 2019.
The Slovakian had made ten appearances in the Super Lig for Istanbul this season and also featured in the Champions League five times for the club.
Skrtel was in the two-tie matches against Manchester United which made them sunk the premier league side into the Europa League following a 2-1 victory.
He was also in the list that played against PSG in a match that was completed a day later than scheduled after players walked off the field in the first time round – following an allegation of racism involving the Romanian fourth official.
He rose to fame at Liverpool where he spent eight-and-a-half years, played 319 games and scored 18 goals for the Reds.
He previously played for Trenčín and Zenit Saint Petersburg, before joining Liverpool for £6.5 million in January 2008.
Skrtel signed for Turkish Süper Lig club, Fenerbahçe, on the 14th July 2016, after his exit from Liverpool for a reported fee of £5 million.
He has won the Russian Premier League and the League Cup, and was named Slovak Footballer of the Year four times.