The government on Tuesday announced the death of the minister of transport, Sidik Mia, and senior member of the government cabinet.
Sidik Mia, 56 years, who tested positive late last week was isolating at home with mild symptoms.
The minister, was also the vice president of the ruling Malawi Congress Party.
Lingson Belekanyama, Local government minister, also succumbed to the disease after a two-week illness.
A source said: “President Lazarus Chakwera is deeply saddened by the demise of two senior cabinet ministers today.”
Malawi is hit my the resurgence of the pandemic with 30% of confirmed cases within the last two weeks, with a total recorded case of 9000 cases and 235 deaths.
The government has blamed the spike on lack of vigilance during the festive season.
Chakwera said: “We are paying the price because many of us are back to the old ways of not wearing masks,” the president said in an address to the nation on Sunday.
“When I say many of us, I am including myself and all of us who are working in government.
“it (coronavirus) has now infected all sectors of society, including members of parliament, members of cabinet, members of the media, and members of the clergy.”
Malawian government was blocked from implementing a lockdown last year by a ruling from a high court that the restrictions would unfairly impact the poorest and most vulnerable members of society.
In Malawi, there are currently restriction of movement or gatherings, and face masks are mandatory but people werr encouraged to wear it.