The club announced on Monday morning that Mourinho and his coaching staff, Joao Sacramento, Nuno Santos, Carlos Lalin and Giovanni Cerra, have been relieved of their duties.
The chairman of the club, Daniel Levy, said: “Jose and his coaching staff have been with us through some of our most challenging times as a club.
“Jose is a true professional who showed enormous resilience during the pandemic. On a personal level I have enjoyed working with him and regret that things have not worked out as we both had envisaged. He will always be welcome here and we should like to thank him and his coaching staff for their contribution.”
“Ryan Mason will take First Team training today and a further update will follow in due course,” he added.
The sack is coming in less than a week to the Carabao Cup final against Manchester City on Sunday.
Mourinho joined the club in November 2019, following the sack of Mauricio Pochettino, signed a deal until the end of the 2023 season.
In his first campaign with the club, Mourinho took Tottenham from 14th position in the Premier League table to finish sixth, thereby securing Europa League qualification, but were knocked out of the 2019-20 Champions League competition at the last-16 stage by RB Leipzig.
The club crashed out of 2020-21 season’s Europa League at the last-16 stage following defeat to Dinamo Zagreb.
As Mourinho leaves the club, the club is seventh in the table, and five points off the Champions League places.
Mourinho had however criticised his players in recent weeks, by accusing major players of hiding in their defeat to Arsenal.
He said: “No intensity, no pressing. In terms of creating attacking football, some important players were hiding. In the second half we only had to improve which we did.”
When Mourinho was asked, after a draw against Newcastle, about Tottenham’s tendency to allow points slip from winning positions, he replied: “Same coach, different players”.
His statement after the Newcastle game: “It was not a problem of fight, it was not a problem of attitude, the players wanted to win but I have to be honest and say I saw things on the pitch, not in terms of attitude but in terms of profile, vision, balance, which belongs to the top players, I didn’t see in every position.”
Mourinho had recently been dodging questions from the media about his side’s weakness.
On his side continuing tendency to drop points, Mourinho said: “That’s what I’m not ready to discuss with you. I think it has to do with some of our qualities as a team, but I’m not ready to discuss with you.”
When pressed on when he would be willing to discuss this matter, Mourinho said “maybe never”.
Mourinho was in charge of the club for only 17 months.