His death was confirmed by his brother, Larry, through a social media statement.
Wilmore was said to have died of coronavirus while battling other health complications. He died at the age of 57 years,
He wrote: “My sweet sweet brother, Marc Edward Wilmore, passed away last night while battling COVID and other conditions that have had him in pain for many years.
“My brother was the kindest, gentlest, funniest, lion of an angel I’ve ever known. I love you little brother.”
Marc joined the team of writing staff of the animated TV series, The Simpsons, at the 13th season, and was still till his demise.
In 2008, Marc won an Emmy as producer for Outstanding Animated Programme for the episode Eternal Moonshine of the Simpson Mind.
He also worked on ‘In Living Color’, ‘The PJs’, and ‘F Is For Family’.
Tributes have poured in for him since the announcement of his death.
His colleague on The Simpson writing staff, Michael Price, wrote: “Another giant talent taken too soon. I had the privilege to work alongside Marc Wilmore on 3 shows (PJs, Simpsons, FIFF) for the better part of the last 23 years and he was THE funniest person in every room.
“And a wonderful man. He is irreplaceable. Rest In Peace, my friend.”
F Is For Family producer, Henry Gammill, added: “I’m devastated by the loss of Marc Wilmore.
“Marc was my favorite – I hung onto his every word. He was empathetic beyond measure, not to mention the funniest one in the room every damn time.
“Warm, genuine, uniquely funny – that was Marc. I love him. It was a joy to be his friend.”